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June 2002

Feature

 


Drugs and Sport
A review of Drug Sport Folio 3rd Edition

Dr Philip Randall

Drug Sport Folio is the 3rd edition of the CDROM produced by iNFOSOURCE, a drug resource on what you can and cannot consume as a sportsperson in South Africa. Dr Philip Randall provides perspectives into sport, doping and the Drug SportFolio.

Firstly lets make it clear right from the start that Drug Sport Folio (DSF) compiled and edited by Marlize Smuts and published by Infosource is not a recipe book for those looking to substance abuse as a means of increasing performance. To do that one should get a degree in biochemistry (a Ph.D. if you want to design drugs yourself); a law degree to cut defense costs when you get caught, and a full frontal lobotomy (major organ failure, sterility and substance dependence are the more palatable conditions that can result) in case you do not get caught quickly enough.

Secondly it is important to recognise that the anti-doping codes used in our sports were written by lawyers, for the use of lawyers, and from the basic premise that you are guilty until proven innocent. You can only prove "innocence" by demonstrating that the laboratory made an error (very difficult), the sample, or sample collection, could have been compromised (difficult) or that the law contains a fundamental flaw (good luck with that one) - it does not equate "ignorance" with "innocence".

I have been involved in the fight against drugs in sport for over 10 years now. Much remains that indicates all is not well in sport. The on going war against ignorance has, however, received a major boost with this top class reference source. Regrettably this publication is only applicable in South Africa. However with the ever increasing numbers of overseas sports men and women flocking to South Africa, the message should rapidly travel worldwide - you know the IOC have a policy of "ignorance is no excuse", with this reference source there is "no longer an excuse to be ignorant".

In the Foreword Professor Tim Noakes eloquently establishes the true purpose of this publication when he discusses the need to avoid the "criminalisation of the innocent".

I took two high profile recent cases of "doping offenses" and looked to see how DSF could, theoretically, have been used by the athletes concerned if (and they did not) occur in South Africa.

The first relates to a recent visitor to South Africa in the form of Trinidad and Tobago sprinter Ato Boldon who was reprimanded (not sanctioned) for the presence of ephedrine in his urine sample. On his web site he apologises for the incident and claims the substance originated from a cold and flu preparation. Within the DSF search engine I typed in ephedrine and received 46 hits. Five where within the anti-doping code and related literature, the remaining 41 where in South African medications. Tonics, Slimming preparations, Ear/Eye/Nasal drops, Bronchodilators/anti-asthmatics gave 11 hits the rest fall under the category Coughs/Colds/Flu. Amongst the latter group where 'obvious' candidates for performance enhancement such as Kiddiekof Syrup and Kernosan Horse-radish Wine Cough Remedy !!! Type in pseudoephedrine and you get an additional 77 hits of which 71 are medications.

The point of the above example is that many preparations - especially in the over the counter cough/cold/flu group - contain prohibited substances. They are there to alleviate the "side-effects" of the active ingredient. The problem is the laboratory test is sensitive enough to detect trace levels of the substance but not the original source or dosage level of that substance.

Type in Coughs/Colds/Flu and you get 271 hits of which 87 are permitted and a further 8 have a warning because of caffeine or alcohol. There is plenty of choice out there and DSF can help make that choice with the same professionalism as you take with your sport.

This reference source repeatedly mentions that it is South African specific and the second scenario I tried again proved the value of DSF.

Alain Baxter recently lost his bronze medal at the Winter Olympics for having the presence of methamphetamine (or methylamphetamine) in his urine. According to press articles this came from the use of a Vicks Inhaler purchased outside the United Kingdom. Using DSF I typed in Vicks and obtained 8 hits relating to 6 Vicks products. One (Medinite Syrup) contained ephedrine (prohibited); two contained alcohol (warning) and 5 are permitted - including the nasal spray produced in South Africa.

Methamphetamine is commonly called "speed" or more correctly the hydrochloride form of d - N- methylamphetamine (not the isomer p-methylamphetamine claimed to be present in the nasal spray in question) is called "speed". The problem for Alain Baxter, and all sports men and women, is that the regulations clearly state "methamphetamine" and frequent use is made of the term "and related substances". To tell which isomer was in his sample is both schoolboy chemistry and totally irrelevant. This publication "Drug Sport Folio" could have prevented the problem from ever arising - if this is a case of "criminalisation the innocent".

What was also pleasing to note was that a start has been made on the ever-increasing area of herbal, alternative medicines and nutritional supplements.

Can you take something that contains Ephedra, Ephedra sinica, Ma-Huang or Sida cordifolia ? They all sound suitably herbal and exotic and they are all the herbal equivalent of ephedrine and will definitely get you into major conflict with the authorities.

The medicinal use of herbs is the root of our modern day pharmacology. The problem also often arises that it is not the "active" ingredient that is the problem but a minor impurity - usually not declared - in many cases because the manufacturer did not even think to test for it - but capable of resulting in a failed dope test.

This reference source is the first I have found that attempts to catalogue such products. DSF lists most of these products as permitted but does, naturally, qualify that rating. As a first attempt it is highly commendable and, hopefully, will receive increased technical support from the manufacturers who often consider such information to be "sensitive".
To put the matter in context the IOC has been testing nutritional supplements throughout 2001 and found 14.8% could lead to a positive dope test and 30 have shown positive for ephedrine. None have any of the prohibited substances listed on the ingredient list. Also the USA Food and Drugs Administration has reported over 1000 cases of toxic reaction and a handful of deaths due to ephedrine in the last few years. Clearly the problem exists and Drug Sport Folio makes a bold attempt to draw the users attention to this hidden danger to the sport.

Like Professor Noakes and many overseas experts I believe more effort should be placed into increased research focussed on identification of true performance enhancing substances - eliminating the false positives if you like. To do this we must inform the sports men and women of the potential dangers to their career waiting in the bathroom cabinet. The IOC performs approximately 100,000 tests per year and gets about 1,000 positives - it has been suggested that they should halve that number and use the time and money (these tests are expensive) to, as Professor Noakes puts it "…. unambiguously identify the recent and long term use of those drugs ….. that really do improve athletic performance". To be able to do this we must first eliminate the threat of accidental ingestion.

This reference source should be considered essential to all involved with sport and apart from the medical practitioners, pharmacists, sports administrators, coaches etc mentioned this reference should find its way to schools and into our tourist industry who cater for the overseas athletes. Someone once said "ignorance is bliss" and it certainly was not the IOC.

As a passing thought; do you know of a product that is available in South Africa and is not listed in this reference source ? I am sure the publishers would be delighted to hear from you.


For more information on DrugSportfolio enter here.







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